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Showing posts from September, 2021

How Cellular Heterogeneity Drives Immune Responses

via The Scientist RSS https://ift.tt/39SoEx6 An expert panel will discuss how single cell multiomic techniques shed new light on immune cell heterogeneity and immune function. https://ift.tt/eA8V8J September 28, 2021 at 10:02PM

The Scientist Speaks - Homing in on New Anticancer Targets

via The Scientist RSS https://ift.tt/3kKzUBQ Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets. https://ift.tt/eA8V8J September 28, 2021 at 08:33PM

Q&A: The Transgenerational Effects of Indigenous Residential Schools

via The Scientist RSS https://ift.tt/3AXK6wu The Scientist spoke with Evan Adams, a First Nations physician, about how the health legacy of oppressive government-owned schools, including his parents' experiences, have influenced his own life. https://ift.tt/eA8V8J September 30, 2021 at 06:52PM

Identical Twins Carry Distinctive Epigenetic Marks: Study

via The Scientist RSS https://ift.tt/3uukXqS Researchers found more than 800 sites in the genome where the twins bore the same chemical tags. https://ift.tt/eA8V8J September 30, 2021 at 06:02PM

DNA in Cell Cytoplasm Implicated in Age-Related Blindness

via The Scientist RSS https://ift.tt/39LmBe6 A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness. https://ift.tt/eA8V8J September 29, 2021 at 11:30PM

Optimizing Protein Function with Combinatorial Variant Libraries

via The Scientist RSS https://ift.tt/3F3Or3p Researchers perform directed evolution using a variant library engineered to avoid complications associated with traditional libraries. https://ift.tt/eA8V8J September 29, 2021 at 10:41PM

Keeping Pace With SARS-CoV-2 Evolution

via The Scientist RSS https://ift.tt/3CUZQRp https://ift.tt/eA8V8J September 29, 2021 at 08:38PM

Straightening Out Messy Protein Gels

via The Scientist RSS https://ift.tt/3mqMcz1 Bis-Tris protein gels permit researchers to obtain high-resolution, publication-ready results. https://ift.tt/eA8V8J September 28, 2021 at 11:02PM

Gene Variant Points to Starvation’s Evolutionary Legacy

via The Scientist RSS https://ift.tt/3icLRi4 Ancient and modern genomes reveal that a variant of the human growth hormone receptor likely helped our ancestors survive when food was scarce. https://ift.tt/eA8V8J September 29, 2021 at 02:38AM

West Nile Virus and Climate Change: It's Complicated

via The Scientist RSS https://ift.tt/3m0hV9G Warmer temperatures are likely to increase the prevalence of the mosquito-borne disease in many places, but not all. https://ift.tt/eA8V8J September 29, 2021 at 12:55AM

Opinion: Policymakers' Harmful Anti-China Obsession

via The Scientist RSS https://ift.tt/3ihNs6d Justifying science funding through the lens of global competition risks fostering racial bias and discrimination. https://ift.tt/eA8V8J September 29, 2021 at 12:52AM

WHO Restarts Investigation of COVID-19 Emergence with New Panel

via The Scientist RSS https://ift.tt/2ZvtNsM A new, more diverse group of researchers is being appointed take over the stalled investigation. https://ift.tt/eA8V8J September 29, 2021 at 12:30AM

Straightening Out Messy Protein Gels  

via The Scientist RSS https://ift.tt/2ZGrIKM https://ift.tt/eA8V8J September 28, 2021 at 11:02PM

Hagfish Slime Cells Tailored to Deter Predation

via The Scientist RSS https://ift.tt/3zQAh1M The Scientist spoke with Chapman University’s Yu Zeng about his lab’s finding that the slime-producing cells of the slippery marine fish vary with the creature’s size, which may be an adaptation to thwart different predators. https://ift.tt/eA8V8J September 28, 2021 at 05:30PM

Customizing and Optimizing PCR for Ideal Results

via The Scientist RSS https://ift.tt/3uhPms9 A PCR optimization kit coupled with custom reagents helps researchers master their PCRs. https://ift.tt/eA8V8J September 27, 2021 at 09:50PM

When the Immune Response Makes COVID-19 Worse

via The Scientist RSS https://ift.tt/2Y2qKb6 If the immune system makes mistake--reacting late or getting the target wrong--it can amplify the damage wrought by SARS-CoV-2. https://ift.tt/eA8V8J September 28, 2021 at 02:30AM

From Imaging to Kinetics: Measuring Calcium Signaling

via The Scientist RSS https://ift.tt/3idOobz Streamlining and automating cell-based assays for measuring intracellular calcium. https://ift.tt/eA8V8J September 27, 2021 at 09:50PM

Optogenetics and mRNA Vaccines Net Lasker Awards

via The Scientist RSS https://ift.tt/3ua1N9q This year's winners are Dieter Oesterhelt, Peter Hegemann, Karl Deisseroth, Drew Weissman, Katalin Karikó, and David Baltimore. https://ift.tt/eA8V8J September 25, 2021 at 04:05AM

Matching Water Purity to Fit Experimental Needs

via The Scientist RSS https://ift.tt/39GFYER Do not overlook water purity as a determinant of experimental outcome. https://ift.tt/eA8V8J September 24, 2021 at 08:52PM

Moderna vs. Pfizer: Is There a “Best” mRNA Vaccine?

via The Scientist RSS https://ift.tt/3i4i7Ux Both of the mRNA vaccines available in the US are highly effective against severe COVID-19, but recent studies suggest that Moderna’s elicits a stronger immune response and might be better at preventing breakthrough infections. https://ift.tt/eA8V8J September 24, 2021 at 07:55PM

Streamlining Cell and Gene Therapy Research

via The Scientist RSS https://ift.tt/3u4C0zw The right tools solve researchers’ challenges and advance therapy development. https://ift.tt/eA8V8J September 24, 2021 at 01:53AM

Ancient Human Footprints in New Mexico Dated to Ice Age

via The Scientist RSS https://ift.tt/3zMIG6J Researchers excavated human footprints out of a small bluff next to a dried-up playa lake and radiocarbon-dated embedded seeds to around 23,000 years ago. Their results suggest that people entered the Americas thousands of years earlier than the accepted estimate. https://ift.tt/eA8V8J September 24, 2021 at 12:19AM

Protein Size Matters

via The Scientist RSS https://ift.tt/3hZaH4A A study probes how genetic duplications that can swell protein length influence human traits such as height and kidney function. https://ift.tt/eA8V8J September 23, 2021 at 11:30PM

Spatial Biology in Physiology and Pathology

via The Scientist RSS https://ift.tt/2XSNFWq Elana Fertig and Sanjay Srivatsan discuss the importance of the spatial dimension for biological systems research. https://ift.tt/eA8V8J September 23, 2021 at 10:15PM

Opinion: Scientists Must Combat Scientific Dogmatism

via The Scientist RSS https://ift.tt/3CIrMHV Correcting misinformation and providing reliable data are collective responsibilities of the research community. https://ift.tt/eA8V8J September 23, 2021 at 09:22PM

Alu Leap May Explain Why Apes Don't Have Tails

via The Scientist RSS https://ift.tt/3u3quo5 A transposable element that jumped into the TBXT gene, which is linked to tail morphology, appears to be to blame for our missing appendage. https://ift.tt/eA8V8J September 23, 2021 at 06:28PM

New HHMI Investigator Cohort Announced

via The Scientist RSS https://ift.tt/2XH0t1u The Howard Hughes Medical Institute appoints 33 new researchers, each of whom will receive roughly $9 million over seven years. https://ift.tt/eA8V8J September 23, 2021 at 03:30PM

Navigating Laboratory Certifications

via The Scientist RSS https://ift.tt/39wn7MK Laboratory certifications are essential for exploratory, preclinical, and clinical studies. https://ift.tt/eA8V8J September 23, 2021 at 01:21AM

DNA Methylation Influences Replication and Genome Organization

via The Scientist RSS https://ift.tt/39uaRg0 A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. https://ift.tt/eA8V8J September 23, 2021 at 01:19AM

Stephen Warren, Icon of Fragile X Research, Dies at 67

via The Scientist RSS https://ift.tt/2XvrHrX He famously identified the genetic mutation that causes the condition in 1991. https://ift.tt/eA8V8J September 22, 2021 at 02:28AM

Book Excerpt from You Bet Your Life

via The Scientist RSS https://ift.tt/39nQAsf In his book's Introduction, physician-scientist Paul A. Offit reviews the unusual constellation of circumstances around the development of COVID-19 vaccines. https://ift.tt/eA8V8J September 21, 2021 at 08:25PM

NIH Changes Extension Policy to Better Support Women PIs

via The Scientist RSS https://ift.tt/3zlG8Mw The revision allows more time on previous extensions due to COVID-19 and other life events such as childbirth that disproportionately impact early-career women in science. https://ift.tt/eA8V8J September 21, 2021 at 04:36AM

An Optimized User Experience for Microbiome Research

via The Scientist RSS https://ift.tt/3Ey403f An all-in-one system simplifies stool collection and stabilizes DNA for microbiome profile analysis. https://ift.tt/eA8V8J September 21, 2021 at 01:15AM

High Performance Ion Mobility Spectrometry for Cleaning Validation

via The Scientist RSS https://ift.tt/39ndYpK Discover how this fast, high-resolution analytical technique meets pharmaceutical cleaning validation needs. https://ift.tt/eA8V8J September 20, 2021 at 11:53PM

A One-Stop Shop for Accurate Genetic Variant Classification

via The Scientist RSS https://ift.tt/3ztjbHf Researchers consult a continuously curated database to determine a variant’s clinical significance. https://ift.tt/eA8V8J September 20, 2021 at 11:37PM

Salty Diet Helps Gut Bugs Fight Cancer in Mice: Study

via The Scientist RSS https://ift.tt/39lOcSL A high-salt diet suppressed the growth of tumors in a mouse model of melanoma, apparently because of an interplay between the gut microbiome and natural killer cells. https://ift.tt/eA8V8J September 20, 2021 at 10:45PM

Morphine Tolerance Pathway Identified in Mice

via The Scientist RSS https://ift.tt/2Xzw7hl Prolonged exposure to morphine triggers cells in the spine to release signaling molecules that increase pain sensitivity and dull the relief of the drug. Blocking this activity could improve pain management. https://ift.tt/eA8V8J September 20, 2021 at 06:08PM

Analyzing Oligonucleotide Purity with Capillary Electrophoresis

via The Scientist RSS https://ift.tt/3nKnADA Identify small impurities introduced by oligonucleotide synthesis prior to experimentation. https://ift.tt/eA8V8J September 18, 2021 at 12:54AM

Serious Infections Linked to Autism: Study

via The Scientist RSS https://ift.tt/3zqvoN2 In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder. https://ift.tt/eA8V8J September 17, 2021 at 11:51PM

To Booster or Not: Scientists and Regulators Debate

via The Scientist RSS https://ift.tt/3kiDYJq President Biden's planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them. https://ift.tt/eA8V8J September 17, 2021 at 04:57AM

NIH Grants $470 Million for Study of Long COVID

via The Scientist RSS https://ift.tt/2VNTEuH The study aims to recruit 40,000 adults and children to get a better sense of the condition that can last weeks or months after infection. https://ift.tt/eA8V8J September 17, 2021 at 02:09AM

Multiomic Single Cell CRISPR Screens Reveal Cancer Evasion Mechanisms

via The Scientist RSS https://ift.tt/2XhDZ7b Researchers use Perturb-CITE-seq to perform powerful multiomic pooled CRISPR screens. https://ift.tt/eA8V8J September 16, 2021 at 09:36PM

Researchers Uncover New Families of Gene-Editing Enzymes

via The Scientist RSS https://ift.tt/3zegHfN The results reveal evolutionary relatives of the Cas9 enzyme now used extensively in biotechnology. https://ift.tt/eA8V8J September 16, 2021 at 02:46AM

Accurate Protein Production Promotes Longevity

via The Scientist RSS https://ift.tt/3hCcb4K Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows. https://ift.tt/eA8V8J September 16, 2021 at 02:30AM

Pioneering Research in E3 Ubiquitin Ligase Biology and Applications to Drug Discovery

via The Scientist RSS https://ift.tt/2VKtrNz Jennifer Johnston discusses how a better understanding of ubiquitin-proteasome system elements can potentially aid neurodegenerative disease therapeutics. https://ift.tt/eA8V8J September 15, 2021 at 10:10PM

Single Cell Resolution Research Solutions

via The Scientist RSS https://ift.tt/3EiOrMJ Unravel genomic and proteomic complexity using single cell approaches. https://ift.tt/eA8V8J September 16, 2021 at 12:44AM

Potty Party: Researchers Show Young Cows Can Be Toilet-Trained

via The Scientist RSS https://ift.tt/3Ek4JFh Ethologist Jan Langbein and his team trained the cattle as a way to keep solid and liquid cattle waste separate--with the goal of reducing ammonia emissions coming from livestock. https://ift.tt/eA8V8J September 15, 2021 at 01:50AM

Detecting Proteins in Their Native Environments

via The Scientist RSS https://ift.tt/3hvpELu A quantitative immunofluorescence assay combines the best aspects of traditional Western blots and ELISAs. https://ift.tt/eA8V8J September 15, 2021 at 01:41AM

2021 Ig Nobel Prizes Honor Decongestant Orgasms, Rhino Transport

via The Scientist RSS https://ift.tt/3hzNZjA A full beard can absorb nearly 40 percent of the shock from a punch to the face, according to one winning study. https://ift.tt/eA8V8J September 15, 2021 at 01:25AM

Finetuning RT-qPCR Workflows to Reliably Detect SARS-CoV-2

via The Scientist RSS https://ift.tt/3kc61u0 An integrated guide to maximize RT-qPCR success rates for viral detection assays https://ift.tt/eA8V8J September 15, 2021 at 01:21AM