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Showing posts from January, 2023

Mitochondrial Metabolism Dictates Neurons’ Growth Rate

via The Scientist RSS https://ift.tt/0xcSeaf Altering the rate of respiration in mitochondria changes how fast neurons grow, and making mouse neurons grow humanlike ones, a study finds.  https://ift.tt/pVWKB2r January 31, 2023 at 04:02AM

How Gut Microbiomes Shape Anti-Tumor Immune Responses

via The Scientist RSS https://ift.tt/MYvIVuh In this webinar, Andrew Y. Koh will discuss the role of the gut microbiome in modulating cancer immunotherapy.  https://ift.tt/pVWKB2r January 27, 2023 at 09:41PM

Immune Cells and ALS: A Balance Between Life and Death

via The Scientist RSS https://ift.tt/F8uJfWo https://ift.tt/pVWKB2r January 30, 2023 at 08:46PM

The Fundamentals of Spectral Flow Cytometry

via The Scientist RSS https://ift.tt/LlOIeMs In this webinar, Mirko Corselli discusses the similarities, differences, and advantages of spectral flow cytometry compared to conventional flow. https://ift.tt/dmEQF5o January 26, 2023 at 08:35PM

Mutations in Autism-Linked Gene Cause Membrane Mischief

via The Scientist RSS https://ift.tt/s6nKMjA Inactivating TAOK1 prompts tentacle-like protrusions to form all over a neuron’s surface, revealing the gene's role in molding the membrane. https://ift.tt/IyornUm January 27, 2023 at 02:05AM

Double Agents: Engineered Bacteria Tackle Pathogenic Biofilms in Mice

via The Scientist RSS https://ift.tt/nu7Rb9Y Mycoplasma pneumoniae with pathogenic genes replaced by biofilm-degrading ones enhance survival in a mouse model of ventilator-associated pneumonia. https://ift.tt/IyornUm January 26, 2023 at 08:50PM

Opioids Recruit the Immune System to Cause Withdrawal Symptoms

via The Scientist RSS https://ift.tt/YFMLHav A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal. https://ift.tt/7BkSGOK January 26, 2023 at 03:00AM

Streamlining Membrane Protein Research with Mass Photometry

via The Scientist RSS https://ift.tt/30wZ7ES Mass photometry advances membrane protein characterization by offering fast and precise mass measurements of samples containing membrane mimetics.  https://ift.tt/7BkSGOK January 24, 2023 at 08:52PM

Detecting Contaminants in Complex Drug Samples

via The Scientist RSS https://ift.tt/I5s90ra By optimizing chromatography and mass spectrometry methods, scientists overcome challenges in identifying contaminants such as N-nitrosamines. https://ift.tt/7BkSGOK January 25, 2023 at 08:23PM

Asthma Drug Helps Mice Retrieve Memories "Lost" to Sleep Deprivation

via The Scientist RSS https://ift.tt/s6pTfmu A study finds roflumilast can reverse sleep deprivation-induced amnesia in mice, hinting at pathways to treating memory loss in people. https://ift.tt/gmkNrZA January 25, 2023 at 01:15AM

Streamlining Membrane Protein Research with Mass Photometry

via The Scientist RSS https://ift.tt/pDRXsmw https://ift.tt/gmkNrZA January 24, 2023 at 08:52PM

Scientists Use Centrifuge to Discover a Hormone

via The Scientist RSS https://ift.tt/xer5Mkp A new method for isolating extracellular fluid aims to discover molecules with therapeutic potential that were previously obscured by highly abundant proteins. https://ift.tt/6JGOdPs January 23, 2023 at 11:51PM

New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatment 

via The Scientist RSS https://ift.tt/1Nc6yRm Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy. https://ift.tt/6JGOdPs January 23, 2023 at 07:30PM

In Vitro Malaria Sporozoite Production May Lead to Cheaper Vaccines

via The Scientist RSS https://ift.tt/cTZtCeE A method for culturing the infectious stage of the Plasmodium lifecycle could increase malaria vaccine production efficiency by tenfold, study authors say.  https://ift.tt/gWJFcHP January 21, 2023 at 02:24AM

Artificial Organs: Innovating to Replace Donors and Dialysis

via The Scientist RSS https://ift.tt/xvPhTjl Scientists employ cutting edge tools and techniques to create artificial organs for research and disease therapeutics. https://ift.tt/gWJFcHP January 20, 2023 at 09:26PM

Fish Oil in Diet Can Cause Hair Loss in Mice, Study Finds 

via The Scientist RSS https://ift.tt/0gCbj4q The oil’s omega-3 fatty acids accumulate in the mice’s skin, triggering an immune response that causes hair loss. https://ift.tt/XhIEdv2 January 19, 2023 at 06:40PM

“Origami” DNA Traps Could Keep Large Viruses From Infecting Cells

via The Scientist RSS https://ift.tt/SWVK0gA By engineering structures out of DNA, scientists could potentially prevent larger viruses, like coronaviruses and influenza viruses, from interacting with cells. https://ift.tt/XhIEdv2 January 19, 2023 at 02:43AM

Opinion: Stopping the Cancer Cells that Thrive on Chemotherapy

via The Scientist RSS https://ift.tt/c4qb8eL Research into how pancreatic tumors adapt to stress could lead to a new treatment approach. https://ift.tt/SbDBXON January 18, 2023 at 02:45AM

A Comprehensive Guide to Proteomics

via The Scientist RSS https://ift.tt/rC5toqQ Deconstructing concepts, approaches, and data analysis in proteomics workflows.   https://ift.tt/H9pkgdC January 17, 2023 at 01:02AM

Neoantigen Prediction for Precision Immunotherapies 

via The Scientist RSS https://ift.tt/nmjZCtJ Learn about the tools and resources researchers use to define, discover, and deploy anti-tumor immunotherapies. https://ift.tt/V17WIev January 13, 2023 at 12:03AM

Rockfish Genes Hold Clues to Human Longevity

via The Scientist RSS https://ift.tt/9ZOhmuQ By analyzing the genomes of 23 remarkably long-lived fish species, a study found two metabolic pathways associated with longevity. https://ift.tt/HPvSW2m January 13, 2023 at 01:32AM

High-Resolution Mass Spectrometry Solutions in Drug Discovery and Development

via The Scientist RSS https://ift.tt/ufONFIY Electron activated dissociation (EAD) and the Zeno trap provide high sensitivity and certainty in mass spectrometry results. https://ift.tt/ZbiLcU1 January 12, 2023 at 12:33AM

Shift Work Early in Life Results in Increased Stroke Severity in Middle Age

via The Scientist RSS https://ift.tt/jUKdgp6 Researchers found that shifted sleep/wake cycles in young rats result in increased functional deficits and mortality following stroke later in life. https://ift.tt/ZbiLcU1 January 12, 2023 at 12:31AM

Overcoming Spheroid and Organoid Generation and Analysis Challenges

via The Scientist RSS https://ift.tt/l6MpnBW An overview of the power and flexibility of live-cell analysis https://ift.tt/ZbiLcU1 January 11, 2023 at 01:28AM

Immunity-Linked Genes Expressed Differently in Brains of Autistic People

via The Scientist RSS https://ift.tt/p9MUalz Data from postmortem brain tissues adds to the evidence that inflammation is associated with autism. https://ift.tt/ZbiLcU1 January 11, 2023 at 10:30PM

A Guide to Mapping the Complexity of the Tumor Microenvironment

via The Scientist RSS https://ift.tt/Ybtd3EO High-quality sample preparation, single-cell analysis, and ultra-high content spatial proteomics for multi-dimensional research workflows. https://ift.tt/ZbiLcU1 January 06, 2023 at 07:52PM

Monkeypox Virus Has Potential to Be Sexually Transmitted

via The Scientist RSS https://ift.tt/RfU2cD7 Researchers discovered monkeypox virus in primate testicular tissues. https://ift.tt/A0XaOYv January 09, 2023 at 09:18PM

Present Your Paper in The Scientist’s Journal Club

via The Scientist RSS https://ift.tt/PhfAxwI Apply today to share your cutting-edge research in The Scientist’s Journal Club. https://ift.tt/A0XaOYv January 09, 2023 at 06:30PM

SNO-y Protein Levels Help Explain Why More Women Develop Alzheimer’s

via The Scientist RSS https://ift.tt/lUDWeQ8 Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses. https://ift.tt/MwrV2Y5 January 07, 2023 at 01:05AM

Single Cell and Spatial Imaging of the Tumor Microenvironment

via The Scientist RSS https://ift.tt/cevYA75 https://ift.tt/MwrV2Y5 January 06, 2023 at 07:52PM

Transfer RNAs Have a Surprising Role in Breast Cancer Growth

via The Scientist RSS https://ift.tt/em8ADSd A particular leucine-ferrying tRNA is more abundant in cancerous cells than healthy ones, and lowering its levels inhibits cancer growth, a study finds. https://ift.tt/VbvIw6H January 05, 2023 at 08:30PM

Advancing Biotherapeutics with Multiomics

via The Scientist RSS https://ift.tt/CwrBSlN Explore how biomolecular processes drive health and disease. https://ift.tt/VbvIw6H January 03, 2023 at 09:54PM

Humans Are Still Evolving Thanks to Microgenes

via The Scientist RSS https://ift.tt/voqStpB A study sheds light on the tiny genes that have evolved in human genomes since we split from our mammalian ancestors. https://ift.tt/0nL49gX January 04, 2023 at 10:13PM

Animals Are Shape-Shifting in Response to a Warming World

via The Scientist RSS https://ift.tt/w152zmY Forced to respond to a climate that’s changing faster than it ever has, it remains unclear whether species’ adaptations can keep pace. https://ift.tt/0nL49gX January 04, 2023 at 01:22AM

Infographic: How Chlamydia Evades Immune Detection

via The Scientist RSS https://ift.tt/pCxhUEJ Chlamydia trachomatis, the bacterium that causes chlamydia, hides from the immune system by cloaking itself in the host cell's membrane then modifying the membrane's protein composition. https://ift.tt/3Ue0b29 January 02, 2023 at 10:30AM