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Showing posts from March, 2023

High-Resolution Microscope Watches Proteins Strut Their Stuff

via The Scientist RSS https://ift.tt/UWewd1x Modification on a high-resolution fluorescent microscopy technique allow researchers to track the precise movements of motor proteins.  https://ift.tt/PJmaLqT March 31, 2023 at 10:10PM

Single Cell Sequencing in a Nutshell????

via The Scientist RSS https://ift.tt/MJ3xqT6 By exploring the inner workings of individual cells, rather than averaging bulk populations, researchers identify rare and important cell subtypes. https://ift.tt/PJmaLqT March 31, 2023 at 07:34PM

Single Cell Sequencing in a Nutshell????

via The Scientist RSS https://ift.tt/peKrJ0y https://ift.tt/PJmaLqT March 31, 2023 at 07:34PM

New Synthetic E. coli Is Immune to Bacteriophage Infection

via The Scientist RSS https://ift.tt/ib48wUa Self-contained synthetic E. coli resistant to viral infection could prove invaluable to the biotechnology industry by increasing product consistency and reducing safety concerns.  https://ift.tt/z0i27NS March 30, 2023 at 08:30PM

COVID-19 Infections May Reshape Genetic Landscape

via The Scientist RSS https://ift.tt/AY0qrm5 SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests.  https://ift.tt/z0i27NS March 30, 2023 at 07:40PM

Translation of “Jumping Genes” Creates Cancer Therapy Targets

via The Scientist RSS https://ift.tt/MwQ7Shk Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up. https://ift.tt/z0i27NS March 30, 2023 at 12:46AM

Advancing Spatial Biology Technology

via The Scientist RSS https://ift.tt/2J3uBK1 How spatial biology techniques evolved over time  https://ift.tt/JMDnjGW March 28, 2023 at 09:41PM

Working Together to Battle Fatty Liver Disorders

via The Scientist RSS https://ift.tt/b8hHst9 Benedetta Artegiani and Delilah Hendriks are forming a joint laboratory group to understand disease mechanisms and treatments through organoid models. https://ift.tt/bLkQNn6 March 24, 2023 at 09:35PM

A Protein-Rich Diet Helps Mice and Flies Sleep More Soundly: Study

via The Scientist RSS https://ift.tt/pQayHW5 The effect appears to be mediated by a gut-secreted peptide that signals to neurons in the brain that modulate the response to mechanical vibrations. https://ift.tt/fFLMBTh March 24, 2023 at 06:35PM

‘Godfather of Genetic Engineering’ Paul Berg Dies at 96

via The Scientist RSS https://ift.tt/OTZSRdv Berg was awarded one-half of the Nobel Prize in Chemistry in 1980 for his work with recombinant DNA technology.  https://ift.tt/fFLMBTh March 24, 2023 at 02:32AM

Translational Research for Neural Implants 

via The Scientist RSS https://ift.tt/quhTEcX John Donoghue and Vasiliki (Vasso) Giagka will discuss the latest bioengineering advances for implantable devices that treat neurological disorders. https://ift.tt/fFLMBTh March 23, 2023 at 12:13AM

Versatile and Sustainable: Cell Counting for the 21st Century

via The Scientist RSS https://ift.tt/WDIgcXS Discover how the latest cell counting technology is reshaping a mundane task for the future. https://ift.tt/fFLMBTh March 23, 2023 at 06:37PM

hCINAP Protein Key to Cellular Senescence: Study

via The Scientist RSS https://ift.tt/zeajP7Y The authors claim that by preventing the formation of senescent cells, the protein could delay aging, but experts are skeptical. https://ift.tt/FREbM3f March 23, 2023 at 06:30PM

Technique Talk: Developing and Optimizing Immunohistochemistry Protocols

via The Scientist RSS https://ift.tt/NQSZv4z Learn about the fundamentals of immunohistochemistry in this workshop for better protocol development and troubleshooting. https://ift.tt/FREbM3f March 22, 2023 at 11:44PM

The Particulars of Cell Culture Particulates

via The Scientist RSS https://ift.tt/o2JWGDp A guide to choosing depth filtration devices for cell culture applications. https://ift.tt/FREbM3f March 20, 2023 at 11:59PM

The Particulars of Cell Culture Particulates

via The Scientist RSS https://ift.tt/TtNeCOo https://ift.tt/ynTRGo3 March 20, 2023 at 11:59PM

Diving Deeper into Tissue Samples with Spatial Context

via The Scientist RSS https://ift.tt/rVqafDs Scientists developed a standardized multiplex immunohistochemistry and RNA in situ hybridization protocol using ChipCytometryTM. https://ift.tt/ynTRGo3 March 16, 2023 at 01:46AM

Uncovering Rare Disease Genetic Pathways with Global Biobanks

via The Scientist RSS https://ift.tt/LjTzD9l Researchers discover new idiopathic pulmonary fibrosis risk factors with multi-ancestry analyses that increase representation of understudied populations. https://ift.tt/ynTRGo3 March 20, 2023 at 08:08PM

Gut Bacterium Linked to Depression in Premenopause

via The Scientist RSS https://ift.tt/gLwTOS8 The opportunistic pathogen Klebsiella aerogenes degrades estradiol and induces depressive-like behavior in mice, a study finds. https://ift.tt/mShtHNP March 17, 2023 at 08:30PM

A Spotlight on Cancer Cell Metabolism

via The Scientist RSS https://ift.tt/vCWp64E In this webinar, Elena Piskounova and Christina Towers discuss the implications of metabolic changes in cancer cells for therapeutic development and efficacy.  https://ift.tt/m5gVE7s March 14, 2023 at 07:25PM

Hormone Therapy Triggers Male Gene Patterns in Transgender Men’s Cells

via The Scientist RSS https://ift.tt/JGecMl5 A study deepens the scientific understanding of how androgens influence breast tissue, which may offer clues to treating breast cancer.  https://ift.tt/7gEs19x March 15, 2023 at 10:57PM

What Could Cause the Next Pandemic?

via The Scientist RSS https://ift.tt/YkseB42 Scientists prepare for the future by filling in the research gaps between zoonotic viral reservoirs, emerging viruses, and human immune defenses. https://ift.tt/7gEs19x March 15, 2023 at 06:29PM

Context Is Key: Unlocking Tissue Complexity with Spatial Biology

via The Scientist RSS https://ift.tt/NMO7Z04 Scientists combine spatially resolved imaging analyses with cutting edge single cell techniques for greater insight into fundamental and disease relevant pathways. https://ift.tt/7gEs19x March 13, 2023 at 10:57PM

Gut Bacteria Help T Cells Heal Muscle: Study

via The Scientist RSS https://ift.tt/9rw0zCm Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery. https://ift.tt/7gEs19x March 14, 2023 at 11:54PM

Context Is Key: Unlocking Tissue Complexity with Spatial Biology

via The Scientist RSS https://ift.tt/mH5eMoQ https://ift.tt/e9cSPN6 March 13, 2023 at 10:57PM

The Role of Adhesion Receptors in Cancer Cannibalism

via The Scientist RSS https://ift.tt/XcFSa4K Contact inhibition of locomotion by adhesion receptors prevents cancer cells from eating each other.  https://ift.tt/e9cSPN6 March 13, 2023 at 09:49PM

Garbage to Guts: The Slow-Churn of Plastic Waste

via The Scientist RSS https://ift.tt/7IhVBsM The winding trail of environmental microplastics is leading researchers to the human digestive ecosystem. https://ift.tt/e9cSPN6 March 13, 2023 at 06:56PM

Parasite Drove Natural Selection in Amazonian Indigenous Groups

via The Scientist RSS https://ift.tt/nOfQWCJ The findings could help researchers understand why some individuals are more vulnerable to deadly Chagas disease. https://ift.tt/e9cSPN6 March 13, 2023 at 06:30PM

How Larval Fruit Fly Brains Convert Sensory Signals to Movement

via The Scientist RSS https://ift.tt/1CHfy2J A wiring map diagrams more than half a million neuronal connections in the first complete connectome of Drosophila and holds clues about which brain architectures best support learning. https://ift.tt/6IQ0swt March 10, 2023 at 09:00PM

Hormone Sobers Up Drunken Mice: Study

via The Scientist RSS https://ift.tt/O3MciSG A hormone naturally induced by alcohol consumption accelerates the recovery of mice after binge drinking by activating neurons involved in arousal and alertness. https://ift.tt/H2Asqu5 March 09, 2023 at 02:15AM

Finally, Scientists Sequence Single Cells with Long-Read Technology

via The Scientist RSS https://ift.tt/8oLKdjh By combining two innovative approaches, researchers can now sequence the full spectrum of mutational differences between individual cells’ genomes. https://ift.tt/H2Asqu5 March 09, 2023 at 01:30AM

Molecular Biologist Michael Green Dies at 69

via The Scientist RSS https://ift.tt/vVkJy4g Beyond his achievements in academia, he also cofounded three pharmaceutical companies and filed 15 patents related to cancer therapeutics.  https://ift.tt/L5YQHWr March 08, 2023 at 02:53AM

Meningitis Bacteria Trigger Headaches, Then Sneak Into the Brain

via The Scientist RSS https://ift.tt/fRwuxG9 Researchers find that bacteria stimulate a headache-causing pain pathway to suppress the immune system and infect the brain.  https://ift.tt/L5YQHWr March 07, 2023 at 03:53AM

Mutated Cohesin Throws DNA Splicing out of Whack, Resulting in Cancer

via The Scientist RSS https://ift.tt/1XZiASV Cohesin mutations cause dysregulations in alternative splicing, contributing to tumor initiation and progression, a study finds.  https://ift.tt/y2YAaU9 March 04, 2023 at 03:14AM

Now AI Can Be Used to Design New Proteins

via The Scientist RSS https://ift.tt/IEZMORo Machine learning can be harnessed to synthesize artificial light-bearing enzymes that actually work in cells. https://ift.tt/y2YAaU9 March 04, 2023 at 12:37AM

Genotype Screening in Songbirds Made Easy

via The Scientist RSS https://ift.tt/j2g7VqT Christien Bowman uses a fast, waste-reducing, and cost-effective DNA preparation method for sex determination in zebra finch. https://ift.tt/y2YAaU9 March 03, 2023 at 08:00PM

Making Sense of Regulations

via The Scientist RSS https://ift.tt/FytauJ5 Knowing what to focus on, what resources are available, and who to talk to for regulatory advice ahead of time can smooth the drug discovery journey. https://ift.tt/FB1W2Hp February 23, 2023 at 08:42PM

The Science of Scaling

via The Scientist RSS https://ift.tt/8IPsxka Incorporating automation can be vital to overcoming scale-up obstacles associated with moving from discovery to manufacturing. https://ift.tt/FB1W2Hp February 23, 2023 at 08:33PM

Observing Cells in Their Natural State with Digital Holographic Cytometry

via The Scientist RSS https://ift.tt/buO37qH Technological and engineering advances let researchers delve deeper into cell function and behavior in physiological and pathological settings. https://ift.tt/wW2iO6m March 01, 2023 at 10:28PM

Mutational Signature Indicates Risk of Kidney Cancer Recurrence

via The Scientist RSS https://ift.tt/mfjR93Z DNA sequencing can identify mutations that predict recurrence of renal cell carcinoma and may help low-risk patients avoid unnecessary treatment, a study finds. https://ift.tt/wW2iO6m March 01, 2023 at 08:30PM

Jumping Genes’ Role in Cancer

via The Scientist RSS https://ift.tt/1E9XtsG Transposons may be key players in how tumors develop and spread, but they also keep cancer at bay in some circumstances. https://ift.tt/wW2iO6m March 01, 2023 at 10:30AM

Cellular Senescence: Why Do Cells Stop Dividing?

via The Scientist RSS https://ift.tt/rDsdvLO Senescent cells undergo major morphological and metabolic changes when at the end of their lifespan.  https://ift.tt/wW2iO6m February 28, 2023 at 10:19PM