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Showing posts from April, 2023

Modulating the Immune Response to Vaccines

via The Scientist RSS https://ift.tt/VUkDXle Researchers uncover innovative natural approaches to fine-tune immunity from vaccination. https://ift.tt/4fA2W7G April 26, 2023 at 05:55PM

Real World Data: Opening New Avenues for Health Research

via The Scientist RSS https://ift.tt/BFbtz86 Scientists and clinicians increasingly use real world data (RWD) to make valuable discoveries that can be applied to the healthcare industry. https://ift.tt/4fA2W7G April 28, 2023 at 07:37PM

A Bacterial Culprit for Rheumatoid Arthritis

via The Scientist RSS https://ift.tt/mRLFwJD Scientists identified a species of Subdoligranulum that may drive disease. https://ift.tt/EedmRtM April 27, 2023 at 09:24PM

Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control

via The Scientist RSS https://ift.tt/wUEdlS6 In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9. https://ift.tt/fDgqG1s April 26, 2023 at 08:00PM

Time for a Change: Evidence-Based Approaches for the Biological Safety Assessment of Medical Devices

via The Scientist RSS https://ift.tt/nmvEUhP In this webinar, Ron Brown discusses the problems with current medical device biological safety assessment approaches and suggests that evidence-based strategies could be the solution.  https://ift.tt/fDgqG1s April 19, 2023 at 06:14PM

Stress Increases Biological Age, But Recovery Can Revert It

via The Scientist RSS https://ift.tt/ecqnLWV A new study relying on DNA methylation clocks suggests that the biological age of mouse and human cells can fluctuate in response to stressful events. https://ift.tt/u0VxHXT April 22, 2023 at 04:04AM

A Novel Immunoassay for Detecting Disease-Relevant Enzymatic Reactions 

via The Scientist RSS https://ift.tt/8LWxDiZ An overview of the Transcreener ADPR assay https://ift.tt/u0VxHXT April 18, 2023 at 01:33AM

Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells

via The Scientist RSS https://ift.tt/zXZMgFx Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice. https://ift.tt/fdFJaRm April 20, 2023 at 10:40PM

Important Players for a Successful PCR

via The Scientist RSS https://ift.tt/Xl5eGVZ Learn about other PCR components—beyond the polymerase—that are essential for optimal results. https://ift.tt/yi8hz4O April 20, 2023 at 06:58PM

New Brain Network Connecting Mind and Body Discovered

via The Scientist RSS https://ift.tt/WYv0nRw A new brain network responsible for complex movements may upend what we know about neural maps in primary motor areas https://ift.tt/yi8hz4O April 19, 2023 at 08:30PM

Advances in Antibody Therapeutics

via The Scientist RSS https://ift.tt/ZGwuqCz Scientists engineer therapeutic antibodies with improved stability and efficacy.  https://ift.tt/nwzqXi1 April 18, 2023 at 06:17PM

Advances in Antibody Therapeutics

via The Scientist RSS https://ift.tt/A7ESIWs https://ift.tt/nwzqXi1 April 18, 2023 at 06:17PM

Optimizing Organoid Models for Basic Research and Translational Applications

via The Scientist RSS https://ift.tt/WQA9j5Y By tracking 3D cultures in real time, researchers obtain reproducible results quickly and efficiently. https://ift.tt/nwzqXi1 April 14, 2023 at 09:58PM

Bacterial Tractor Beams Bring Radiation to Tumors

via The Scientist RSS https://ift.tt/ZUn9XLC Colonizing tumors with engineered bacteria may allow researchers to target sites currently inaccessible to radionuclide therapy. https://ift.tt/iI9AuCw April 17, 2023 at 06:00PM

Immune Molecule Alters Cellular Makeup of Human Brain Organoids

via The Scientist RSS https://ift.tt/1dQCZNu The changes may help explain the link between maternal infection and autism, though more research is needed. https://ift.tt/iI9AuCw April 17, 2023 at 04:30PM

Cellecta, Inc. Launches DriverMap™

via The Scientist RSS https://ift.tt/ucf5ZIr Adaptive Immune Receptor (AIR) Assay to Provide Greater Insights into Immune Repertoire Diversity by Profiling T-Cell and B-Cell Receptor Variability in Genomic DNA https://ift.tt/no3sN2G April 15, 2023 at 12:57AM

Hibernating Bears Provide Clue to Preventing Serious Clots in Humans

via The Scientist RSS https://ift.tt/L5dHDKk Low levels of the clotting factor HSP47 protect the sleeping giants from blood clots, and the same may be possible for humans and other mammals. https://ift.tt/yZxngzv April 13, 2023 at 11:30PM

Science Summarized: The Mosaic Brain

via The Scientist RSS https://ift.tt/XzF4pdV Mutations that accumulate as one ages contribute to various neurological disorders. https://ift.tt/Q2omXip April 13, 2023 at 09:20PM

Science Summarized: Putting Cells in Spatial Context

via The Scientist RSS https://ift.tt/YQrjohU Dive deeper into tissue samples with high resolution, high-plex spatial phenotyping. https://ift.tt/Q2omXip April 13, 2023 at 09:13PM

Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice

via The Scientist RSS https://ift.tt/e1mzioh Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds. https://ift.tt/Q2omXip April 12, 2023 at 11:30PM

How Cells in the Skin Team Up To Fight Pathogens

via The Scientist RSS https://ift.tt/La32lYm Immune cells and pain neurons form complex partnerships to protect our bodies from pathogens, new research reveals. https://ift.tt/Q2omXip April 12, 2023 at 08:30PM

Getting to the Root of Skin Healing

via The Scientist RSS https://ift.tt/BD0OeES Scientists reveal how the intimate link between hair follicles and wound healing is more than skin deep. https://ift.tt/LzND9kU April 11, 2023 at 06:30PM

“Cryptic Transcription”: How Aging Cells Express Fragments of Genes

via The Scientist RSS https://ift.tt/BSsW8Ag Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined. https://ift.tt/QGt5wz8 April 07, 2023 at 12:15AM

Selecting the Right PARP Assay

via The Scientist RSS https://ift.tt/S3LTCwX Poly (ADP-ribose) polymerase (PARP) inhibitors are promising cancer therapeutics, and there are several options for testing their effectiveness in vitro. https://ift.tt/lFuSb5g April 05, 2023 at 08:34PM

Self-Charging Battery Battles Tumors in Mice

via The Scientist RSS https://ift.tt/71PhNKG A battery that charges itself in salty fluids and reacts with oxygen can improve how well some drugs treat small tumors, a study finds. https://ift.tt/fKrDzBW April 05, 2023 at 02:50AM

Cell-Free DNA in Clinical Diagnostics

via The Scientist RSS https://ift.tt/0U7GXhC Advancements in measuring DNA in bodily fluids create new opportunities for understanding disease. https://ift.tt/fKrDzBW March 29, 2023 at 08:26PM

Infographic: How “Selfish” Centromeres Alter Inheritance

via The Scientist RSS https://ift.tt/QTuYZLN Research on so-called selfish genetic loci is providing scientists with greater insight into the biology of chromosome segregation and inheritance. https://ift.tt/2LN9Sbm April 03, 2023 at 09:30AM

The Components of Effective qPCR

via The Scientist RSS https://ift.tt/YbSTWZ8 Putting the pieces together for molecular diagnostics and infectious disease research https://ift.tt/PJmaLqT March 27, 2023 at 11:32PM